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Original Article
Perioperative risk factors for acute kidney injury following liver resection surgery
1 Consultant Anesthetist, Honorary Senior Lecturer Visiting Professor, King’s College Hospital UK
2 BSc (Hons) Medical Physiology, Kings College London UK
Address correspondence to:
Amy Rene Gomes
BSc (Hons), Kings College London, Hull York Medical School,
UK
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Article ID: 100017A05ZM2019
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How to cite this article
Milan Z, Gomes AR. Perioperative risk factors for acute kidney injury following liver resection surgery. Edorium J Anesth 2019;5:100017A05ZM2019.ABSTRACT
Aim: To investigate and identify potential perioperative risk factors for developing acute kidney injury (AKI) in patients undergoing liver resection.
Methods: This is a retrospective analysis of a single cohort centre of 110 patients undergoing liver resection. The Kidney Disease: Improving Global Outcomes (KDIGO) criteria was used for acute kidney injury (AKI) diagnosis. Preoperative, intraoperative and postoperative variables were recorded. These were then statistically analysed through univariate and multivariate regression analysis.
Results: Acute kidney injury occurred in 17 patients (15.45%). Twelve patients were stage 1 AKI (70.6%), four were reportedly in stage 2 (23.5%) and one patient was in stage 3 (5.9%). Risk factors were identified through univariate regression analysis were ASA status (p=0.023), weight (p=0.001), gender (p=0.01) and baseline serum creatinine (p=0.031). Weight and Americal Society of Anaesthesiologists (ASA) status were also identified in the multivariate regression analysis as being independent predictors for the development of AKI (p=0.014, p=0.021 respectively).
Conclusion: Acute kidney injury stage 1–3 is a common complication following hepatectomy. Risk factors including obesity and presence of comorbidities can contribute to the development of AKI and thus may provide appropriate targets for perioperative treatment.
Keywords: Acute kidney injury, Complications, Liver surgery, Obesity, Postoperative
SUPPORTING INFORMATION
Author Contributions
Zoka Milan - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Amy Rene Gomes - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patients for publication of this article.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Zoka Milan et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
